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2.2 In patients with moderate hepatic impairment (Child-Pugh B: 7-9), the maximum recommended dosage of XADAGO is 50 mg once daily.

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The infant almost invariably receives no benefit from this form of exposure and is considered to be an 'innocent bystander'.

Drug transfer from maternal plasma to milk is, with rare exceptions, by passive diffusion across biological membranes.

Opipramol should not be used during lactation period, since the active ingredient passes into the milk in small quantities.

Opipramol acts as a high affinity sigma receptor agonist, primarily at the σ receptors cause neurotransmitter release.

The recommended starting dosage of XADAGO is 50 mg administered orally once daily (at the same time of day), without regard to meals.

at 1-888-492-3246 or FDA at 1-800-FDA-1088 or gov/medwatch.

Approval: 2017 XADAGO is a monoamine oxidase type B (MAO-B) inhibitor indicated as adjunctive treatment to levodopa/carbidopa in patients with Parkinson’s disease (PD) experiencing “off” episodes (1) Most common adverse reactions (incidence on XADAGO 100 mg/day at least 2% greater than placebo) were dyskinesia, fall, nausea, and insomnia (6.1) To report SUSPECTED ADVERSE REACTIONS, contact US World Meds, LLC, Inc.

After two weeks, the dosage may be increased to 100 mg once daily, based on individual need and tolerability.

Its anxiolysis becomes prominent after only one to two weeks of chronic administration.

Upon first commencing treatment, opipramol is rather sedating in nature due to its antihistamine properties, but this effect becomes less prominent with time.

If a dose is missed, the next dose should be taken at the same time the next day.

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